Vardenafil stands as a highly potent and selective inhibitor of PDE5, demonstrating superior bioavailability and rapid absorption compared to similar medications. As an FDA-approved medication specifically designed for erectile dysfunction treatment, vardenafil belongs to a class of drugs known as phosphodiesterase 5 (PDE5) inhibitors.
What is Vardenafil?
Vardenafil is the active ingredient formerly marketed under the brand name Levitra®, though the brand version is no longer available in the United States. The medication received FDA approval in 2003 and has since proven its effectiveness in treating erectile dysfunction through its selective action on specific enzyme pathways.
How Vardenafil Works
The mechanism of action involves inhibiting the enzyme responsible for breaking down cyclic GMP in the corpus cavernosum. During sexual stimulation, nitric oxide releases from nerve endings, activating enzymes that increase cyclic GMP synthesis. This process leads to:
Verdenafil reaches maximum plasma concentration in 0.6–0.9 hours, with effects lasting approximately 4-5 hours. Sexual stimulation is essential for the medication to work effectively.
All PDE5 inhibitors require a prescription and should be taken under medical supervision. Common side effects may include headache, upset stomach, and flushing.
Several key factors influence the cost of vardenafil, making it essential for patients to understand these variables when seeking affordable treatment options.
Brand Name vs Generic Versions
The price difference between brand-name and generic vardenafil is substantial. While brand-name versions like Levitra® previously cost between USD 633.00 to USD 1,623.00 for ten to thirty 10mg tablets, generic alternatives now offer significant savings. Generic vardenafil can cost as little as USD 35.30, representing a 91% reduction from the average retail price of USD 395.62.
Dosage and Quantity
Dosage strength and quantity significantly impact pricing:
Pharmacy Pricing Variations
Pharmacy selection and payment methods substantially affect final costs. The National Average Drug Acquisition Cost (NADAC) for a 10mg tablet
Oral vs. Brand Name
Dosage strengths and quantity play a crucial role in sales decision-making. The average retail price for a 10mg tablet of vardenafil is USD 35.30 for a 2-tablet supply
In The Pharmapom
In vitro studies have shown Vardenafil to effectively treat erectile dysfunction in both men with and without diabetes. works by increasing blood flow to the penis, helping to achieve and maintain an erection during sexual stimulation
Generic vs. brand name
brand name frequently play a significant role in price. Generic vardenafil can cost as little as USD 35.30, representing a 91% increase from the average retail price of USD 395.62
Costco of Australia offers vardenafil as a prescription drug. The provider provides cost estimates and expert medical advice, and can refer you to a specialist if needed. While vardenafil is often compared to alternative ED drugs, the two are effective tools in the treatment of both a and patient alike.
It is used to treat adult male erectile dysfunction, a condition that involves difficulties getting or maintaining an erection
The recommended starting dose for Levitra is 10 mg
It must be taken 25-60 minutes prior to sexual activity. With sexual stimulation, you can achieve an erection anywhere from 25 minutes up to 5 hours after taking Levitra
Do not take Levitra if:
If you are allergic to vardenafil.
If you are taking medicines such as nitrates or amyl nitrate
If you are taking medicines to treat HIV
If you are over 75 and taking antifungal medication
If you have severe heart or liver problems
if you are undergoing dialysis
If you have recently had a stroke or heart attack
If you suffer from low blood pressure
If your family has a history of degenerative eye disease
If you have ever had a condition involving loss of vision from insufficient blood supply
vardenafil
Vardenafil 20 mg
4 tablets
tablets
GTIN :0000001001442
Weight :0.100 KG
Generic :VardenafilPrescription required
Vardenafil 20 mg | 4 tabletsUses :Treat erectile dysfunctionTreatment of symptoms of erectile dysfunction
Dosage :Erectile dysfunctionManagement of symptoms of erectile dysfunction
Prescribed for Treatment of erectile dysfunctionHow it works :Levitra reduces the effect of phosphodiesterase type 5 (PDE5) on the smooth muscle in the penis, which is involved in erection and premature ejaculation.
Active ingredient :LevitraGeneric
Pharmacology:Pharmacodynamics:Levitra (Vardenafil) is a phosphodiesterase (PDE-5) inhibitor, it has pharmacological effect via inhibition of cyclic guanosine monophosphate (cGMP). When administered with physiological doses at the maximum dose in the dose-titration study (MIC 2.26 and D3.27 as well as D2 as well as D0 as the absorption is not sufficient to justify the continued use of dose reduction of dose reduction treatment. In clinical trials (CUNY 8-week double blind study), there was no evidence of therapeutic benefit of the dose increase study in CUNY-92, CUNY-93 and CUNY-93/92/S01. In the dose-titration study (MIC 3.12 and D3.27 as well as D2 as well as D0 as the duration of the MIC 3.12 study), no significant difference was observed between the MIC 3.12 and D3.27 doses in treatment of patients with erectile dysfunction. Dizziness and lightheadedness may be a symptom of erectile dysfunction.
Pharmacological/Nervousment:
Mechanism of Action:Levitra (Vardenafil) belongs to the phosphodiesterase-5 (PDE-5) inhibitor class, which have been found to be useful in pulmonary arterial smooth muscle relaxation and to widen blood vessels and to increase blood flow to the penis. In addition, it has potent and selective blocking of PDE-5, that increase levels of cGMP which results in increased ability of patients to achieve and maintain an erection. The effect of Levitra (Vardenafil) is due to modulate the renal and smooth muscle function and cGMP levels are also increased, resulting in erectile dysfunction. Levitra (Vardenafil) also enhances arterial pressure and an erection is expected within several hours. Levitra (Vardenafil) is a dose-- and treatment duration-relieving, it is administered in the dose and time-options available for the MIC 3.12 as well as in duration of the effect MIC 3.12 as D3.27.
Dosage:
Spectrum:Efficacy and Tolerability:
Side effects:Prolonged treatment of ED (MIC 3.12), flushing and headache may be expected. No serious adverse events were identified.Safety and Tolerability:
Adverse events:Major Premature E
: If Levitra (Vardenafil) is taken for four or more weeks, patients may experience symptoms of erectile dysfunction such as flushing, headache and diarrhea. Flushing may be a sign of an underlying cause for the treatment to be delayed.Interaction:
Mechanism of action:Levitra (Vardenafil) blocks the effect of phosphodiesterase (PDE-5) enzyme which promotes the relaxation and dilation of the blood vessels of the body. cGMP levels are increased which results in blood vessels relaxation and increased blood flow to the penis. cGMP is also reduced which results in erectile dysfunction. Therefore, Levitra (Vardenafil) when administered to patients in clinical studies at the maximum dose in the dose-titration study. D3 as well as D2 as well as D0, the duration of the effect in the dose and time-benefit study. It is not possible to determine precisely when the effect of a dose reduction will be felt, it can be felt within the next four or more weeks. Dizziness and lightheadedness may be symptoms of erectile dysfunction. Flushing, headache and diarrhea are some of the most common side effects of Levitra (Vardenafil. No drug-drug interactions were found between the two drugs.
Flushing, headache, dyspepsia, nasal congestion, and acid regurgitation may be expected. No serious adverse events were reported to be seen in the dose range of four to eight weeks being given with meals and snacks.
Levitra Vardenafil is used to treat erectile dysfunction or male impotence. Levitra Vardenafil works by relaxing the muscles in the walls of blood vessels to increase blood flow, assisting a male in keeping a sufficient penile erection for sexual activity. This medication does not increase sexual desire and works when sexual stimulation occurs.
The recommended dose for Levitra is 10mg taken orally 25-60 minutes before sexual activity. Levitra has shown to take effect within about 15 minutes of taking the medication and, lasts up to 8-10 hours. The dose of Levitra can be decreased to 10mg or increased to a maximum of 20mg, based on the effectiveness and side effects.
is essential for a response to treatment. The maximum daily dose is 20mg once a day (per 24 hours). For Geriatric patients (65 years or older) the initial dose is 5mg once a day as needed about one hour before sexual activity. The doctor may adjust the dosage based on your medical history and side effects. Levitra can be taken with or without food. Do not eat grapefruit or drink grapefruit juice when taking his medication unless your doctor or pharmacist says you may do so safely.
| Medication | Onset | Duration |
|---|---|---|
| Vardenafil | 30-60 minutes | 4-5 hours |
This medication should be stored at room temperature away from moisture and light. Levitra should not be kept in the bathroom. Keep away from children and pets.
Many medications cause side effects and not everyone may experience side effects of Levitra. The following side effects can be mild and manageable.
If you are a heart patient, sexual activity could put extra strain on your heart. If you experience the following serious side effects while having sex, stop and get medical help right away. The side effects include:
Some patients may experience serious side effects, if you experience these get medical help right away. Serious side effects include:
Some patients experience side effects not listed. If you have any concerns regarding Levitra contact your physician.
Take Note: This medicine is available only with a valid doctor's prescription.Take his medication to achieve the required effect.For Geriatric patients (65 years or over)
For Geriatric patients (over 24 years of age)
For Geriatric patients (over 4 years of age)
For Geriatric patients (overconditions where his medication does not start working properly), his medication is:
Vardenafil 10mg (for Geriatric patients upon recommendation)
Era to dose:
The start and stop time for Geriatric patients (over 24 years of age)
To ensure his medication is effective, take his medication at the same time daily.
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